Initial release: August 7, 2001
Directors: Peter Farrelly, Bobby Farrelly
Running time: 95 minutes
MPAA rating: PG
Initial DVD release: November 13, 2001
Starring (Cast): The film's voice cast Chris Rock as Osmosis "Ozzy" Jones, Laurence Fishburne as Thrax, David Hyde Pierce as Drixenol "Drix" Koldreliff, Brandy Norwood as Leah Estrogen, William Shatner as Mayor Phlegmming, Ron Howard as Tom Colonic, Joel Silver as the Police Chief.
Storyline: Frank Detorre (Bill Murray) is a widowed slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Much to the frustration of his young daughter, Shane (Elena Franklin), he eats compulsively unhealthy and has minimal concern for germs or disease. While trying to eat a hard-boiled egg with mayonnaise and salt, it is stolen from him by a chimpanzee. He gets it back, but not before it falls into the filth of the chimp's habitat. When Shane is disgusted by him about to eat it he uses the "ten second rule" as a justification for the unsanitary act.
Inside Frank's body, Osmosis "Ozzy" Jones (Chris Rock), an agent of the Frank PD, is an adventure-seeking white blood cell with a good sense of humor. He is a rebel cop, frequently disobeying authority to do what he thinks is right. He is often mocked by his fellow cops due to his rebellious nature. He has been relocated to the mouth to fight against germs entering the body via ingestion after he induced Frank to vomit all over Shane's science and P. E. teacher, Mrs. Boyd (Molly Shannon) at the school's science fair. This was considered a false alarm because he had been the only one to suspect an incoming pathological threat from the raw oyster Frank had eaten from one of the displays. After several newcomer germs, believed to be gingivitis, hijack a "squad car" in the mouth, Osmosis and another officer in an FPD helicopter, are pulled into the lungs by a massive yawn while in pursuit. After the germs evade capture and pass into "Immunity's" jurisdiction, Osmosis disobeys direct orders as he pursues the germ on foot and accidentally triggers a major cramp in Frank's leg.
Frank Detorre (Bill Murray) is a widowed slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Much to the frustration of his young daughter, Shane (Elena Franklin), he eats compulsively unhealthy and has minimal concern for germs or disease. While trying to eat a hard-boiled egg with mayonnaise and salt, it is stolen from him by a chimpanzee. He gets it back, but not before it falls into the filth of the chimp's habitat. When Shane is disgusted by him about to eat it he uses the "ten second rule" as a justification for the unsanitary act.
Inside Frank's body, Osmosis "Ozzy" Jones (Chris Rock), an agent of the Frank PD, is an adventure-seeking white blood cell with a good sense of humor. He is a rebel cop, frequently disobeying authority to do what he thinks is right. He is often mocked by his fellow cops due to his rebellious nature. He has been relocated to the mouth to fight against germs entering the body via ingestion after he induced Frank to vomit all over Shane's science and P. E. teacher, Mrs. Boyd (Molly Shannon) at the school's science fair. This was considered a false alarm because he had been the only one to suspect an incoming pathological threat from the raw oyster Frank had eaten from one of the displays. After several newcomer germs, believed to be gingivitis, hijack a "squad car" in the mouth, Osmosis and another officer in an FPD helicopter, are pulled into the lungs by a massive yawn while in pursuit. After the germs evade capture and pass into "Immunity's" jurisdiction, Osmosis disobeys direct orders as he pursues the germ on foot and accidentally triggers a major cramp in Frank's leg.
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